The Global Platform for the Prevention of Autoimmune Diabetes |
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Welcome to the very first issue of our GPPAD Science-Newsletter. From now on, we will keep you updated on the most important developments of GPPAD projects and research. If you are interested in receiving this newsletter in the future, please register HERE GPPAD is committed to data and bio-sample sharing, which may also be interesting for your research. Please send any questions or feedback to cc@gppad.org. Of course, we are excited to share our journey towards a world without type 1 diabetes with you! Enjoy reading! Your GPPAD team |
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WE RESEARCH. WE DEVELOP. WE FIGHT. |
FOR A WORLD WITHOUT TYPE 1 DIABETES. |
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GPPAD - WHO WE ARE, WHAT WE DO |
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The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) is a research organization that unites academic institutions and hospitals in five European countries under the lead of Helmholtz Zentrum München. We …- provide an international infrastructure to enable type 1 diabetes (T1D) primary prevention trials
- identify infants with an elevated genetic risk of developing T1D
- offer participation in randomized controlled trials aiming to reduce the incidence of islet autoimmunity and T1D in children
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Screening study for the risk of developing T1D |
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GPPAD conducts screening for genetic predisposition of T1D in infancy using a polygenic SNP risk score: The study is known as Freder1k (Germany, Belgium, Poland), Ingr1d (UK) and Astr1d (Sweden), respectively.- GPPAD screening for high genetic risk of developing T1D is active in five countries in Europe (Belgium, Germany, Poland, Sweden, UK). The GPPAD investigators and collaborators have established a screening network in their respective regions with local affiliate partners such as obstetric clinics, neonatologists, primary care pediatricians, and newborn screening laboratories to perform the actual screening for T1D risk.
- Genetic risk is determined using a combination of family history and up to 51 SNPs. DNA extraction from filter paper blood spots and genetic typing are done at LGC, UK.
- High genetic risk is defined as having a risk above 10 % (25 fold higher than the general population) of developing multiple beta cell autoantibodies (stage 1 T1D) by 6 years of age.
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A total of 1.15 % of screened infants were identified to have a high genetic risk. By TODAY 243,499 children have been screened with a monthly rate of 8,000 throughout the last 12 months: |
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Belgium (Flanders): 12,783 |
Germany (Bavaria, Lower Saxony, Saxony, Thuringia): 130,669 |
Sweden (Skane): 12,662 |
Poland (Warsaw): 74,442 |
UK: 15,403 |
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POINT: Primary Oral Insulin Trial |
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Children with high genetic risk for T1D and their parents or guardians are asked to participate in the oral immunotherapy study POInT. The POInT study aims to train the immune system, induce immune tolerance through daily sensitization with insulin powder, and thereby reduce the incidence of beta-cell autoantibodies and diabetes in childhood. |
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Faculty of Medicine, Technical University Munich, Germany |
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CT-IMP, phase IIb, randomized controlled trial |
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1:1 (oral inuslin or placebo) |
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up to 7 years of age or until the end of the trial |
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7.5 mg (2 months), 22.5 mg (2 months), 67.5 mg (until end of intervention) or placebo |
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T1D (multiple beta cell autoantibodies or diabetes) |
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GPPAD Biobank and Data Sharing |
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GPPAD has established a data- and biobank repository. The GPPAD biobank contains extensive sample material (Serum, Plasma, RNA, PBMC) of the study participants. For application to access GPPAD data, please click here For application to access the GPPAD Biobank, please click here |
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Participating Institutions |
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Dresden (Saxony & Thuringia): Prof Dr Ezio Bonifacio & Prof Dr Reinhard Berner Leuven (Flanders): Prof Dr Kristina Casteels Munich (Bavaria): Prof Dr Anette-Gabriele Ziegler & Dr Christiane Winkler Warsaw: Prof Dr Agnieszka Szypowska & Dr Mariusz Ołtarzewski |
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Hanover (Lower Saxony): Prof Dr Olga Kordonouri & Prof Dr Thomas Danne Malmö (Skane): Prof Dr Helena Elding Larsson & Prof Dr Markus Lundgren |
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Oxford: Prof Dr Matthew Snape & Dr Manu Vatish |
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The GPPAD Coordinating Centre is located at the Institute of Diabetes Research, Helmholtz Zentrum München: |
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Director: Prof Dr Anette-Gabriele Ziegler |
Deputy Director: Prof Dr Peter Achenbach |
External Expert in Study Statistics: Prof Jörg Hasford |
Data Management: Dr Florian Haupt |
Ethical and Regulatory Affairs: Stefanie Arnolds |
Central Office Coordination: Dr Melanie Gündert |
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If you no longer want to receive the newsletter, please unsibscribe here. If this email is not displyed correctly, please click here. |
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GPPAD - Institute of Diabetes Research, Helmholtz Zentrum München
Ingolstädter Landstraße 1 85764 Neuherberg Deutschland
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